Ammonium Hydroxide → 6-(Trifluoromethyl)pyridazin-3-amine
反応式
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:7]=1.[OH-].[NH4+:13]>C1COCC1>[F:9][C:8]([F:11])([F:10])[C:5]1[N:4]=[N:3][C:2]([NH2:13])=[CH:7][CH:6]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
A mixture of 3-chloro-6-trifluoromethyl-pyridazine (1.6 g, 8.8 mmol) (prepared by a procedure similar to that described in Tetrahedron, 1999, 55 (52), 15067-15070) and ammonium hydroxide (30 ml) in THF (10 ml) was heated at 100° C. in a microwave reactor (Emrys Optimizer; 0-9 Barr) for 1 h. After this period, the reaction mixture was evaporated and the residue extracted with dichloromethane. The combined extracts were dried (MgSO4), filtered and the solvents evaporated in vacuo to give D6 (1.3 g, 93%). C5H4F3N3 requires 163; Found 164 (MH+)
後処理
- customprepared by a procedure similar to
- waitAfter this period
- customthe reaction mixture was evaporated
- extractionthe residue extracted with dichloromethane
- dry with materialThe combined extracts were dried (MgSO4)
- filtrationfiltered
- customthe solvents evaporated in vacuo
出典と根拠
- ORDレコード
- ord-7157ef4b97684c03a32b00946bae8736
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08940743B2
反応ノート
読み込み中…