10-Oxa-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione → 10-Oxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
反応式
[CH:1]12[O:10][CH:7]([CH:8]=[CH:9]1)[CH:6]1[CH:2]2[C:3](=[O:12])[CH2:4][C:5]1=[O:11]>CO.[Pd]>[CH:7]12[O:10][CH:1]([CH2:9][CH2:8]1)[CH:2]1[CH:6]2[C:5](=[O:11])[CH2:4][C:3]1=[O:12]参加物
4
実験手順
(1RS,2SR,6RS,7SR)-10-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (2.1 g, 12.8 mmol), prepared in Example 1, Step 5, is dissolved in warm methanol (180 ml) and the mixture is allowed to cool to room temperature. The mixture is then hydrogenated in the presence of 5% palladium on carbon (approx. 50 mg) at 3.5 bar for 4 hours. The catalyst is removed by filtration through diatomaceous earth and the filtrate is concentrated under reduced pressure to afford (1RS,2SR,6RS,7SR)-10-oxatricyclo[5.2.1.02,6]decane-3,5-dione.
後処理
- customThe catalyst is removed by filtration through diatomaceous earth
- concentrationthe filtrate is concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-270b0e202ca2433f86f4bee9e8495a05
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08940913B2
反応ノート
読み込み中…