2,4-Difluoro-5-nitrobenzonitrile → 5-Amino-2,4-difluorobenzonitrile

HRID 1430959ノート

反応式

HRID 1430959 の反応式
[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([N+:11]([O-])=O)=[CH:6][C:3]=1[C:4]#[N:5]>CO.[Pd]>[NH2:11][C:7]1[C:8]([F:10])=[CH:9][C:2]([F:1])=[C:3]([CH:6]=1)[C:4]#[N:5]

参加物

4

反応物 1

HCID 118197152,4-Difluoro-5-nitrobenzonitrile

生成物 1

HCID 668484065-Amino-2,4-difluorobenzonitrile収率 70.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A suspension of 2,4-difluoro-5-nitrobenzonitrile (1.0 g, 5.43 mmol) and Pd/C 10% (0.1 g, 0.94 mmol) in MeOH (20 mL) was hydrogenated (balloon) for 5 hr. This was filtered and the solvent was removed. Flash chromatography on silica gel eluting with hexane containing 20% EtOAc gave 5-amino-2,4-difluorobenzonitrile (0.59 g) as a light yellow solid.

後処理

  1. customfor 5 hr
  2. filtrationThis was filtered
  3. customthe solvent was removed

出典と根拠

ORDレコード
ord-a87e70cddc4d42adb4346236172dae72
出典データセット
uspto-grants-2015_01
特許番号
US08940736B2

反応ノート

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