HCID 66742608、化合物 → 5-(4-Methylpiperazin-1-YL)pyrazin-2-amine
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[N:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=2)[CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:13]=[N:12][C:11]([NH2:14])=[CH:10][N:9]=2)[CH2:6][CH2:7]1参加物
4
実験手順
2-(4-methylpiperazin-1-yl)-5-nitropyrazine (328 mg, 1.47 mmol) was dissolved in MeOH (15 ml) at room temperature. Pd/C (10%) (50 mg) was added while the reaction mixture was stirred. The reaction mixture was placed under a H2 balloon and stirred at rt for 1.5 hrs. The reaction mixture was filtered through celite and washed with MeOH (30 mL). The filtrate was stripped and dried under vacuum after azeotroping with toluene twice to give a light brown gummy material (280 mg, yield 89%).
後処理
- stirringstirred at rt for 1.5 hrs
- filtrationThe reaction mixture was filtered through celite
- washwashed with MeOH (30 mL)
- customdried under vacuum
- customafter azeotroping with toluene twice
出典と根拠
- ORDレコード
- ord-fd0efb1481cb44a28c32f41cfa974e0c
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08940741B2
反応ノート
読み込み中…