4-Methyl-1-(6-nitropyridin-3-yl)piperidin-4-ol → 1-(6-Aminopyridin-3-yl)-4-methylpiperidin-4-ol
反応式
[CH3:1][C:2]1([OH:17])[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[N:10][C:11]([N+:14]([O-])=O)=[CH:12][CH:13]=2)[CH2:4][CH2:3]1>CO.[Pd]>[NH2:14][C:11]1[N:10]=[CH:9][C:8]([N:5]2[CH2:6][CH2:7][C:2]([CH3:1])([OH:17])[CH2:3][CH2:4]2)=[CH:13][CH:12]=1参加物
4
実験手順
A solution of 4-methyl-1-(6-nitropyridin-3-yl)piperidin-4-ol (807 mg, 3.67 mmol) in methanol (15 ml) was hydrogenated at 50 psi with 10% Pd/C (117 mg, 110 umol) overnight. The catalyst was filtered off and the resultant filtrate was concentrated in vacuo to afford 1-(6-aminopyridin-3-yl)-4-methylpiperidin-4-ol. The product was carried to next reaction without further purification.
後処理
- filtrationThe catalyst was filtered off
- concentrationthe resultant filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-03f7c6dec55541d687658239228a8d63
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08940741B2
反応ノート
読み込み中…