Triethylamine → (R)-2-(prop-2-ynyl)-1,2-dihydropyrido[2,3-b]pyrazin-3(4H)-one
反応式
[N+:1]([C:4]1[C:9]([NH:10][C@H:11]([CH2:16][C:17]#[CH:18])[C:12](OC)=[O:13])=[CH:8][CH:7]=[CH:6][N:5]=1)([O-])=O.[NH4+].[Cl-].CCN(CC)CC>CO.[Fe]>[CH2:16]([C@@H:11]1[C:12](=[O:13])[NH:1][C:4]2[N:5]=[CH:6][CH:7]=[CH:8][C:9]=2[NH:10]1)[C:17]#[CH:18]参加物
6
実験手順
A suspension of (R)-methyl 2-(2-nitropyridin-3-ylamino)pent-4-ynoate (220 mg, 0.883 mmol), iron (296 mg, 5.30 mmol) and NH4Cl in 10 mL of MeOH was heated to reflux for 4 h. After cooling to room temperature, 0.5 mL of NEt3 was added and the solution was stirred overnight. The solvent was evaporated and the residue was redissolved with EtOAc and filtered through a pad of silica gel. The filtrate was evaporated to dryness the title compound that was used directly in the next step.
後処理
- temperaturewas heated
- temperatureto reflux for 4 h
- customThe solvent was evaporated
- dissolutionthe residue was redissolved with EtOAc
- filtrationfiltered through a pad of silica gel
- customThe filtrate was evaporated to dryness the title compound that
出典と根拠
- ORDレコード
- ord-28fc1f21fe1742f498e9319eafd45948
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07612060B2
反応ノート
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