Sodium Hydroxide → 4,5,6,7-Tetrahydro-1,3-benzothiazole-5-carboxylic acid

HRID 1432351ノート

反応式

HRID 1432351 の反応式
[OH-].[Na+].[S:3]1[C:7]2[CH2:8][CH2:9][CH:10]([C:12]([O:14]CC)=[O:13])[CH2:11][C:6]=2[N:5]=[CH:4]1>CO>[S:3]1[C:7]2[CH2:8][CH2:9][CH:10]([C:12]([OH:14])=[O:13])[CH2:11][C:6]=2[N:5]=[CH:4]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 13424804HCID 13424804、化合物

生成物 1

HCID 685523074,5,6,7-Tetrahydro-1,3-benzothiazole-5-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

6 ml of 2N NaOH are added to a solution of 0.42 g of ethyl 4,5,6,7-tetrahydrobenzothiazole-5-carboxylate [952203-30-8] and 24 ml of MeOH at room temperature. After 6 hours, the reaction mixture is evaporated. The residue is acidified with 4N HCl, diluted with water and extracted with ethyl acetate (2×)—the combined organic phases are dried with sodium sulphate and evaporated. The crude title compound is obtained from the residue.

後処理

  1. customthe reaction mixture is evaporated
  2. additiondiluted with water
  3. extractionextracted with ethyl acetate (2×)—the combined organic phases
  4. dry with materialare dried with sodium sulphate
  5. customevaporated

出典と根拠

ORDレコード
ord-2d395f3bf35e485a8aeafc3f85cc22c1
出典データセット
uspto-grants-2009_11
特許番号
US07612088B2

反応ノート

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