5-Isopropyl-1,3,4-thiadiazol-2-amine → N-[5-(5-Isopropyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-indan-2-yl]-acetamide

HRID 1432532ノート

反応式

HRID 1432532 の反応式
[C:1]([NH:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([S:14](Cl)(=[O:16])=[O:15])[CH:11]=2)[CH2:6]1)(=[O:3])[CH3:2].[CH:18]([C:21]1[S:25][C:24]([NH2:26])=[N:23][N:22]=1)([CH3:20])[CH3:19]>N1C=CC=CC=1.CN(C)C1C=CN=CC=1>[CH:18]([C:21]1[S:25][C:24]([NH:26][S:14]([C:10]2[CH:11]=[C:12]3[C:7](=[CH:8][CH:9]=2)[CH2:6][CH:5]([NH:4][C:1](=[O:3])[CH3:2])[CH2:13]3)(=[O:16])=[O:15])=[N:23][N:22]=1)([CH3:20])[CH3:19]

参加物

5

反応物 2

HCID 1471515-Isopropyl-1,3,4-thiadiazol-2-amineHCID 203478562-Acetamido-2,3-dihydro-1h-indene-5-sulfonyl chloride

生成物 1

HCID 57933501N-[5-(5-Isopropyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-indan-2-yl]-acetamide

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 1049Pyridine溶媒

反応条件

温度
60 °C

実験手順

2-Acetylamino-indan-5-sulfonyl chloride (500 mg) was dissolved in 5 ml of pyridine and a catalytic amount of 4-dimethylamino pyridine was added. After addition of 262 mg of 5-isopropyl-[1,3,4]thiadiazol-2-ylamine the mixture was stirred at 60° C. for 1 hour followed by evaporation. The resulting crude material was purified by column chromatography (silica gel, eluent: dichloromethane:methanol=95:5).

後処理

  1. customfollowed by evaporation
  2. customThe resulting crude material was purified by column chromatography (silica gel, eluent: dichloromethane:methanol=95:5)

出典と根拠

ORDレコード
ord-ee159bc95827477e88e26ff5296e81ef
出典データセット
uspto-grants-2009_11
特許番号
US07612104B2

反応ノート

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