Formaldehyde → (RS)-6-Carboxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C@@H:7]([C:9]([OH:11])=[O:10])[NH2:8].[CH2:12]=O>>[S:1]1[C:2]2[CH2:6][CH:7]([C:9]([OH:11])=[O:10])[NH:8][CH2:12][C:3]=2[CH:4]=[CH:5]1参加物
3
反応条件
- 温度
- 60 °C
実験手順
A suspension of (D,L) 3-(2-thienyl)-alanine (302 mg, 1.77 mmol) in 37% aq. HCHO (4 mL) was heated at 60° C. for 2 h. The suspension became clear. It was concentrated in vacuo to give the titled compound (323 mg), which was used in the next step without further purification. MS 184.3 (M+H)
後処理
- concentrationIt was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-a8f032a3ef6c42788b3757bfadf6681b
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07612089B2
反応ノート
読み込み中…