Sodium borohydride → HCID 54519295、化合物

HRID 1432955ノート

反応式

HRID 1432955 の反応式
[BH4-].[Na+].[C:3]([O:7][C:8]([N:10]1[C:18]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[CH:12]=[C:11]1[CH2:19][N:20]1[C:25](=[O:26])[CH2:24][N:23]([S:27]([CH:30]=[CH:31][C:32]2[S:33][C:34]([Cl:37])=[CH:35][CH:36]=2)(=[O:29])=[O:28])[CH2:22][CH:21]1[C:38](OC)=[O:39])=[O:9])([CH3:6])([CH3:5])[CH3:4].C(OC(N1C2C=CN=CC=2C=C1CN1C(=O)CNCC1C(OC)=O)=O)(C)(C)C.ClC1SC(C=CS(Cl)(=O)=O)=CC=1>CO>[C:3]([O:7][C:8]([N:10]1[C:18]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[CH:12]=[C:11]1[CH2:19][N:20]1[C:25](=[O:26])[CH2:24][N:23]([S:27]([CH:30]=[CH:31][C:32]2[S:33][C:34]([Cl:37])=[CH:35][CH:36]=2)(=[O:29])=[O:28])[CH2:22][CH:21]1[CH2:38][OH:39])=[O:9])([CH3:5])([CH3:6])[CH3:4]

参加物

6

反応物 4

HCID 4311764Sodium borohydrideHCID 54182443HCID 54182443、化合物HCID 544630642-(5-Chlorothiophen-2-yl)ethenesulfonyl chlorideHCID 69028555HCID 69028555、化合物

生成物 1

HCID 54519295HCID 54519295、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium borohydride (0.005 g, 0.13 mmol) is added to a solution of 2-{4-[2-(5-chloro-thiophen-2-yl)-ethenesulfonyl]-2-(±)-methoxycarbonyl-6-oxo-piperazin-1-ylmethyl}-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester (0.04 g, 0.07 mmol), (prepared from 2-(2-(±)-methoxycarbonyl-6-oxo-piperazin-1-ylmethyl)-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester, EXAMPLE 71, and 2-(5-chloro-thiophen-2-yl)-ethenesulfonyl chloride, EXAMPLE 3, using the procedure described in EXAMPLE 214, Part A) in MeOH (3 mL) at RT. The reaction mixture is stirred for 6 h then quenched with water and concentrated in vacuo. The crude product (0.04 g) is taken onto the next step without further purification.

後処理

  1. customat RT
  2. customthen quenched with water
  3. concentrationconcentrated in vacuo
  4. customThe crude product (0.04 g) is taken onto the next step without further purification

出典と根拠

ORDレコード
ord-bee0f9d895c041f8850757b9cd95aef4
出典データセット
uspto-grants-2009_11
特許番号
US07612075B2

反応ノート

読み込み中…