Sodium Bicarbonate → Ethyl piperazine-1-acetate
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.C(=O)(O)[O-].[Na+]>FC(F)(F)C(O)=O>[CH2:18]([O:17][C:15](=[O:16])[CH2:14][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[CH3:19]参加物
4
実験手順
A solution of 4-ethoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester in 90% trifluroacetic acid (5 ml) was stirred for 3 h. The mixture was basified with saturated sodium bicarbonate solution and concentrated. The residue was triturated with ethylacetate (30 ml) and filtered. The filtrate was concentrated to leave piperazin-1-yl-acetic acid ethyl ester as a yellow oil (ca 1.5 g)
後処理
- concentrationconcentrated
- customThe residue was triturated with ethylacetate (30 ml)
- filtrationfiltered
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-af938514c5d94ba69279ae45187d08c5
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07612201B2
反応ノート
読み込み中…