HCID 178449972、化合物 → HCID 178514703、化合物
反応式
C([NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:35]=[CH:34][C:18]2[NH:19][C:20]([CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)=[N:21][C:17]=2[CH:16]=1)(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[F:33][C:30]([F:31])([F:32])[C:27]1[CH:28]=[CH:29][C:24]([O:23][CH2:22][C:20]2[NH:19][C:18]3[CH:34]=[CH:35][C:15]([C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=4[S:6]([NH2:5])(=[O:8])=[O:7])=[CH:16][C:17]=3[N:21]=2)=[CH:25][CH:26]=1参加物
3
実験手順
A solution of N-tert-butyl-2-[2-(4-trifluoromethyl-phenoxymethyl)-1H benzoimidazol-5-yl]-benzenesulfonamide (40.0 mg, 0.80 mmol) in trifluoroacetic acid (4 mL) was heated at 75° C. for 2 h. The reaction mixture was concentrated under reduced pressure. The resulting TFA salt was diluted with methanol and passed though a sodium bicarbonate cartridge to afford the title compound as the free base (33.8 mg, 95% yield).
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- additionThe resulting TFA salt was diluted with methanol