Methanesulfonyl chloride → Ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

HRID 14335ノート

反応式

HRID 14335 の反応式
[NH2:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1.C(N(CC)C(C)C)(C)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>ClCCl>[CH3:21][S:22]([NH:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1)(=[O:24])=[O:23]

参加物

5

反応物 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 319549Ethyl 2-amino-1,3-oxazole-4-carboxylate

生成物 1

HCID 21086093Ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a 20 ml screw cap vial was added (1 g, 5.8069 mmoles) ethyl 2-amino-1,3-oxazole-4-carboxylate, (10 ml) dichloromethane and (1.39 ml, 7.9797 mmoles, 1.25 eq.) N,N-diisopropylethylamine. To the reaction was then added (0.545 ml, 7.0415 mmoles, 1.1 eq.) methanesulfonyl chloride, and the reaction was agitated for 14 hours. The reaction was then evaporated to dryness and purified using a Biotage silica gel column, resulting in (272 mg) of ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate.

後処理

  1. customTo a 20 ml screw cap
  2. customThe reaction was then evaporated to dryness
  3. custompurified
  4. customresulting in (272 mg) of ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

出典と根拠

ORDレコード
ord-d9638ebdcd4f4839b8b9e1f57a937acf
出典データセット
uspto-grants-2010_06
特許番号
US07727997B2

反応ノート

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