(2S,3R)-3-(benzyloxy)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid → (S)-N-(2-Chloro-4-iodo-phenyl)-2-[(R)-4-(4-cyclopropylmethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-methyl-butyramide

関与物質

役割	名称	HCID	仕込み量
反応物	(2S,3R)-3-(benzyloxy)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid	HCID 16213170	—
反応物	(R)-tert-Butoxycarbonylamino-[4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-phenyl]-acetic acid	HCID 67001404	—
反応物	(2S,3S)-2-{(R)-2-amino-2-[4-((R)-2,3-dihydroxy-propoxy)-phenyl]-acetylamino}-N-(2-chloro-4-iodo-phenyl)-3-phenyl-butyramide	HCID 69006543	—
生成物	(S)-N-(2-Chloro-4-iodo-phenyl)-2-[(R)-4-(4-cyclopropylmethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-methyl-butyramide	HCID 57935190	—

反応手順

Prepared by the same method as described in example 3 except that (i) 2-chloro-4-iodo-aniline was used in place of 4-bromo-2-chloro-aniline in step 1, (ii) (S)-2-tert-butoxycarbonylamino-3-methyl-butyric acid was used in place of (S,S)-2-tert-butoxycarbonylamino-3-phenyl-butyric acid in step 1, and (iii) (R)-tert-butoxycarbonylamino-(4-cyclopropylmethoxy-phenyl)-acetic acid (prepared as described in example 109) was used in place of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid in step 2.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07612212B2
出典データセット	uspto-grants-2009_11
ORD ID	ord-f987c67e83fc44d683a9e83891cbbe72
出典メモ	uspto-grants-2009_11