Sodium Hydroxide → 2-Bromo-1-(3,3-dimethylpiperidin-1-yl)ethanone

HRID 1434127ノート

反応式

HRID 1434127 の反応式
[CH3:1][C:2]1([CH3:8])[CH2:7][CH2:6][CH2:5][NH:4][CH2:3]1.[OH-].[Na+].[Br:11][CH2:12][C:13](Cl)=[O:14]>ClCCl>[Br:11][CH2:12][C:13]([N:4]1[CH2:5][CH2:6][CH2:7][C:2]([CH3:8])([CH3:1])[CH2:3]1)=[O:14]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 709423,3-DimethylpiperidineHCID 89602Bromoacetyl chloride

生成物 1

HCID 233637862-Bromo-1-(3,3-dimethylpiperidin-1-yl)ethanone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3,3-dimethylpiperidine (250 mg) in dichloromethane (3 ml) was added an aqueous solution of 5N sodium hydroxide (1.1 ml), bromoacetyl chloride (0.2 ml) was added dropwise thereto on an ice bath, and the solution was stirred for 1 hour at room temperature. The solution was extracted with diethyl ether, then sequentially washed with an aqueous solution of 10% citric acid and brine, dried over anhydrous magnesium sulfate, and then the solvent was evaporated in vacuo to provide the title compound (420 mg).

後処理

  1. additionwas added dropwise
  2. extractionThe solution was extracted with diethyl ether
  3. washsequentially washed with an aqueous solution of 10% citric acid and brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-bd575141ec2545f1a41d20106f3a3984
出典データセット
uspto-grants-2009_11
特許番号
US07612114B2

反応ノート

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