Resorcinol → 4,4'-Dimethoxy-2-hydroxybenzophenone

反応式

[C:1]1(C=CC=C(O)C=1)O.COC1C=CC(C(Cl)=O)=CC=1.[OH:20][C:21]1[CH:26]=[C:25]([OH:27])[CH:24]=[CH:23][C:22]=1[C:28]([C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1)=[O:29].CI>>[OH:20][C:21]1[CH:26]=[C:25]([O:27][CH3:1])[CH:24]=[CH:23][C:22]=1[C:28]([C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1)=[O:29]

参加物

反応物 4

HCID 5054Resorcinol

HCID 6328Methyl iodide

HCID 7477p-Anisoyl chloride

HCID 350227(2,4-Dihydroxyphenyl)(4-methoxyphenyl)methanone

生成物 1

HCID 961544,4'-Dimethoxy-2-hydroxybenzophenone

実験手順

Synthesized from resorcinol and 4-methoxybenzoyl chloride according to an analogous synthetic method to Preparation Example 66, (2,4-dihydroxyphenyl)(4-methoxyphenyl)methanone (9.7 g) and methyl iodide (13.1 g) were used according to an analogous synthetic method to Example 383 to provide the title compound (7.0 g).