Ammonium Chloride → 4-amino-2,3-dihydro-1H-inden-2-yl acetate

HRID 1434559

反応式

HRID 1434559 の反応式
[C:1]([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[N+:14]([O-])=O)[CH2:6]1)(=[O:3])[CH3:2].[Cl-].[NH4+]>C(O)C.O.C(OC(=O)C)C.[Fe]>[C:1]([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:14])[CH2:6]1)(=[O:3])[CH3:2]

参加物

7

反応物 2

HCID 25517Ammonium ChlorideHCID 132395834-nitro-2,3-dihydro-1H-inden-2-yl acetate

生成物 1

HCID 132395844-amino-2,3-dihydro-1H-inden-2-yl acetate

試薬・触媒・溶媒 4

HCID 23925Iron触媒HCID 702Ethanol溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
90 °C

実験手順

To a mixture of 4-nitro-2,3-dihydro-1H-inden-2-yl acetate (100 mg, 0.45 mmol) and ammonium chloride (100 mg) in ethanol (6 ml) and water (3 ml) was added iron powder (300 mg) portionwise at room temperature. The mixture was stirred at 90° C. for 1 hour, and after cooled to room temperature, the mixture was diluted with ethylacetate. The mixture was filtered through a pad of celite, and the filtrate was washed with brine, dried over MgSO4, filtered, and concentrated under reduced pressure to obtain 4-amino-2,3-dihydro-1H-inden-2-yl acetate.

後処理

  1. temperatureafter cooled to room temperature
  2. filtrationThe mixture was filtered through a pad of celite
  3. washthe filtrate was washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-57ffff16dce048048ddc75e42ca245dc
出典データセット
uspto-grants-2009_11
特許番号
US07615557B2

関連ノート

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