Sodium Hydroxide → HCID 57935821、化合物
反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[CH2:13][CH3:14])[C:6]([O:8]C)=[O:7])#[N:2].[OH-].[Na+]>CO.O>[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[CH2:13][CH3:14])[C:6]([OH:8])=[O:7])#[N:2]参加物
5
実験手順
Methyl 3-cyano-4-ethyl-benzoate (D45) (1.92 g) was dissolved in MeOH (50 mL) before adding 1M NaOH solution (15.24 mL) and stirring the resulting mixture overnight at room temperature, under argon. The reaction mixture was diluted with water, and extracted with EtOAc. The aqueous layer was acidified to pH1 using 2M HCl before extracting with EtOAc. The combined extracts were washed with brine, dried over MgSO4 and the solvent evaporated to dryness in vacuo to afford the title compound (1.63 g). 1H NMR (CDCl3) δ 1.35 (3H, t), 2.97 (2H, q), 7.49 (1H, d), 8.24 (1H, dd), 8.36 (1H, d).
後処理
- extractionextracted with EtOAc
- extractionbefore extracting with EtOAc
- washThe combined extracts were washed with brine
- dry with materialdried over MgSO4
- customthe solvent evaporated to dryness in vacuo
出典と根拠
- ORDレコード
- ord-9bcb3cfd8019479ca41afac51f31fd03
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07615550B2
反応ノート
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