Sodium borohydride → HCID 68704632、化合物

HRID 1434591ノート

反応式

HRID 1434591 の反応式
[BH4-].[Na+].[CH3:3][S:4]([C:7]1[CH:31]=[CH:30][C:10]2[N:11]([CH:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[O:23])[CH2:16][CH2:15]3)[CH:12]=[N:13][C:9]=2[CH:8]=1)(=[O:6])=[O:5]>C(O)C>[CH3:3][S:4]([C:7]1[CH:31]=[CH:30][C:10]2[N:11]([CH:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[OH:23])[CH2:16][CH2:15]3)[CH:12]=[N:13][C:9]=2[CH:8]=1)(=[O:6])=[O:5]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 57935976HCID 57935976、化合物

生成物 1

HCID 68704632HCID 68704632、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium borohydride (189 mg) was added to a solution of 3-{4-[5-(methylsulfonyl)-1H-benzimidazol-1-yl]piperidin-1-yl}-1-phenylpropan-1-one (2.07 g) in ethanol (40 ml) at 0° C., the mixture was allowed to warm to room temperature and was stirred for 16 hours. The reaction mixture was evaporated to dryness, the residue was redissolved in dichloromethane and washed with water (15 ml) and brine (15 ml) and dried. Removal of the solvent gave 3-{4-[5-(methylsulfonyl)-1H-benzimidazol-1-yl]piperidin-1-yl}-1-phenylpropan-1-ol, 2.1 g, M+H 414.

後処理

  1. customThe reaction mixture was evaporated to dryness
  2. dissolutionthe residue was redissolved in dichloromethane
  3. washwashed with water (15 ml) and brine (15 ml)
  4. customdried
  5. customRemoval of the solvent

出典と根拠

ORDレコード
ord-3ae6950eaf34440caacf3571db161d47
出典データセット
uspto-grants-2009_11
特許番号
US07615555B2

反応ノート

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