Benzyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate → 1-(Piperidin-4-yl)imidazolidin-2-one
反応式
[O:1]=[C:2]1[NH:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:12][CH2:11][N:10](C(OCC2C=CC=CC=2)=O)[CH2:9][CH2:8]1>C(O)C.[Pd]>[NH:10]1[CH2:9][CH2:8][CH:7]([N:3]2[CH2:4][CH2:5][NH:6][C:2]2=[O:1])[CH2:12][CH2:11]1参加物
4
実験手順
A solution of benzyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate (3.2 g) in ethanol (200 ml) was hydrogenated under a hydrogen filled balloon with 20% palladium on charcoal as catalyst. The catalyst was filtered and the filtrate evaporated to dryness to give the title compound as a white solid, yield 1.6 g.
後処理
- filtrationThe catalyst was filtered
- customthe filtrate evaporated to dryness
出典と根拠
- ORDレコード
- ord-26da20d065b84c89b7c4bff88de12523
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07615555B2
反応ノート
読み込み中…