Methyl iodide → 3-(t-Butoxycarbonylamino)-2-methoxypropyl Triisopropylsilyl Ether

反応式

[CH:1]([Si:4]([O:11][CH2:12][CH:13]([OH:23])[CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])([CH:8]([CH3:10])[CH3:9])[CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].[CH3:24]I>>[CH:8]([Si:4]([O:11][CH2:12][CH:13]([O:23][CH3:24])[CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])([CH:5]([CH3:7])[CH3:6])[CH:1]([CH3:3])[CH3:2])([CH3:9])[CH3:10]

参加物

反応物 2

HCID 6328Methyl iodide

HCID 579366063-(t-Butoxycarbonylamino)-2-hydroxypropyl Triisopropylsilyl Ether

生成物 1

HCID 579365643-(t-Butoxycarbonylamino)-2-methoxypropyl Triisopropylsilyl Ether収率 62%

実験手順

Using a procedure analogous to Example 57-B, 3-(t-butoxycarbonylamino)-2-hydroxypropyl triisopropylsilyl ether and methyl iodide gave the title compound (13 g, 62%).

出典と根拠

ORDレコード: ord-d4197aed26de4ca885f5552edc3b8199
出典データセット: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07615568B2

反応ノート

読み込み中…