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HRID 1435236作成日：2026年10月27日

Thiophene-3-sulfonyl Chloride → [4-Amino-2-[1-(thiophene-3-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

https://huagongshe.com/reaction/1435236

反応式

関与物質

役割名称HCID仕込み量
反応物Thiophene-3-sulfonyl ChlorideHCID 2776378—
反応物[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanoneHCID 9997668—
生成物[4-Amino-2-[1-(thiophene-3-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanoneHCID 58777610—

反応手順

The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone, Example 59, and 3-thiophenesulfonyl chloride (Maybridge) by the procedure described in Example 152. HR-MS (ES, m/z) calculated for C21H23FN5O4S2 [(M+H)+] 492.1170, observed 492.1175.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07615634B2
出典データセットuspto-grants-2009_11
ORD IDord-c85ca3cd9bf940e9a1b07c3c888dbfcf
出典メモuspto-grants-2009_11