Sodium Hydroxide → N-cyclopropylmorpholine-2-carboxamide
反応式
[OH-].[Na+].[CH:3]1([NH:6][C:7]([CH:9]2[O:14][CH2:13][CH2:12][N:11](C(OCC3C4C=CC=CC=4C4C3=CC=CC=4)=O)[CH2:10]2)=[O:8])[CH2:5][CH2:4]1>CO>[CH:3]1([NH:6][C:7]([CH:9]2[O:14][CH2:13][CH2:12][NH:11][CH2:10]2)=[O:8])[CH2:5][CH2:4]1参加物
4
実験手順
NaOH (1 mL, 2 M, 2.0 mmol) was slowly added to a solution of 9H-fluoren-9-ylmethyl 2-[(cyclopropylamino)carbonyl]morpholine-4-carboxylate (1.0 g, 2.6 mmol) in MeOH (70 mL) at ambient temperature. The reaction mixture was stirred for 3 h and the solvent was concentrated. The product was recovered in water (50 mL) and the mixture was neutralized to pH 7 using HCl solution. The product was extracted with EtOAc and dried over anhydrous Na2SO4. The solvent was concentrated to provide the title compound that was used for the next step without further purification. Yield: 0.8 g.