4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl [2-({[4-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate

HRID 1435623

反応式

HRID 1435623 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[F:13][C:14]([F:26])([F:25])[C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1>>[F:26][C:14]([F:13])([F:25])[C:15]1[CH:16]=[CH:17][C:18]([S:21]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:23])=[O:22])=[CH:19][CH:20]=1

参加物

3

反応物 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27773994-(Trifluoromethyl)benzenesulfonyl chloride

生成物 1

HCID 2814007Ethyl [2-({[4-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate

実験手順

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-trifluoromethylbenzenesulfonyl chloride according to METHOD A, giving 0.14 g (33%) of an off-white solid after recrystallization from acetone/ether/petroleum ether: mp 174° C.; MS (Ionspray, [M+H]+) m/z 395; Anal. Calcd (found) for C14H13F3N2O4S2: C, 42.6 (42.4)%, H, 3.3 (2.8)%, N, 7.1 (6.8)%

出典と根拠

ORDレコード
ord-f7fa9f1e3ccc4fcfacbb9d2fa9059ea9
出典データセット
uspto-grants-2009_11
特許番号
US07618961B2

関連ノート

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