(4-Bromo-phenyl)-[4-chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-YL]-amine → 4-(5-Chloro-2-methyl-phenyl)-6-methyl-[1,3,5]triazin-2-yl-amine

HRID 1435737

反応式

HRID 1435737 の反応式
BrC1C=CC([NH:8][C:9]2[N:14]=[C:13](Cl)[N:12]=[C:11]([C:16]3[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=3[CH3:23])[N:10]=2)=CC=1.[CH3:24][Mg]Br>O1CCCC1>[Cl:22][C:20]1[CH:19]=[CH:18][C:17]([CH3:23])=[C:16]([C:11]2[N:12]=[C:13]([CH3:24])[N:14]=[C:9]([NH2:8])[N:10]=2)[CH:21]=1

参加物

4

反応物 2

HCID 10179730(4-Bromo-phenyl)-[4-chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-YL]-amineHCID 178418573HCID 178418573、化合物

生成物 1

HCID 1317266584-(5-Chloro-2-methyl-phenyl)-6-methyl-[1,3,5]triazin-2-yl-amine収率 53.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The reaction of the title compound of Example 20 (200 mg, 0.49 mmol) with methyl magnesium bromide (3 M in diethyl ether, 1 ml, 3 mmol) in tetrahydrofuran (4 ml) using the method described in Example 22 provided the title compound (62 mg, 32% yield). 1H NMR (DMSO-d6) 10.37 (s, 1H), 7.85 (s, 1H), 7.71 (m, 2H), 7.47-7.54 (m, 3H), 7.38 (m, 1H), 2.53 (s, 3H), 2.50 (s, 3H).

出典と根拠

ORDレコード
ord-ccbf3a93a6df488a900119955d9ad630
出典データセット
uspto-grants-2009_11
特許番号
US07618968B2

関連ノート

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