(4-Bromo-phenyl)-[4-chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-YL]-amine → 4-(5-Chloro-2-methyl-phenyl)-6-ethyl-[1,3,5]triazin-2-yl-amine

HRID 1435738

反応式

HRID 1435738 の反応式
BrC1C=CC([NH:8][C:9]2[N:14]=[C:13](Cl)[N:12]=[C:11]([C:16]3[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=3[CH3:23])[N:10]=2)=CC=1.[CH2:24]([Mg]Br)[CH3:25]>O1CCCC1>[Cl:22][C:20]1[CH:19]=[CH:18][C:17]([CH3:23])=[C:16]([C:11]2[N:12]=[C:13]([CH2:24][CH3:25])[N:14]=[C:9]([NH2:8])[N:10]=2)[CH:21]=1

参加物

4

反応物 2

HCID 10179730(4-Bromo-phenyl)-[4-chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-YL]-amineHCID 178418443HCID 178418443、化合物

生成物 1

HCID 1317266594-(5-Chloro-2-methyl-phenyl)-6-ethyl-[1,3,5]triazin-2-yl-amine収率 36.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The reaction of the title compound of Example 20 (200 mg, 0.49 mmol) with ethyl magnesium bromide (1 M in diethyl ether, 7.5 ml, 7.5 mmol) in tetrahydrofuran (2 ml) using the method described in Example 22 provided the title compound (44 mg, 22% yield). 1H NMR (CDCl3) 7.80 (m, 1H), 7.48 (d, J=8.8 Hz, 2H), 7.38 (d, J=8.8 Hz, 2H), 7.09-7.12 (m, 2H), 2.79 (q, J=7.4 Hz, 4H), 1.13 (t, J=7.0 Hz, 3H).

出典と根拠

ORDレコード
ord-a969a80698714633a00c8666835230fd
出典データセット
uspto-grants-2009_11
特許番号
US07618968B2

関連ノート

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