Hydrazine hydrate (1:1) → 5-Chloropyrazine-2-carbohydrazide

HRID 1435782ノート

反応式

HRID 1435782 の反応式
C[O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([Cl:11])=[CH:7][N:6]=1)=O.O.[NH2:13][NH2:14]>CO>[Cl:11][C:8]1[N:9]=[CH:10][C:5]([C:3]([NH:13][NH2:14])=[O:2])=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 406081Methyl 5-chloropyrazine-2-carboxylate

生成物 1

HCID 457897975-Chloropyrazine-2-carbohydrazide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-chloro-pyrazine-2-carboxylic acid methyl ester (10.02 g, 58.25 mmol) and hydrazine monohydrate (12.5 mL, 250 mmol) were dissolved in methanol (400 mL) and the reaction mixture heated to reflux for 48 hours. The reaction mixture was then filtered and the precipitate collected dried in vacuo to yield the title compound, 5.01 g (50%).

後処理

  1. temperaturethe reaction mixture heated
  2. temperatureto reflux for 48 hours
  3. filtrationThe reaction mixture was then filtered
  4. customthe precipitate collected
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-90f36bffd1c045c7b8c2b08a54a649d1
出典データセット
uspto-grants-2009_11
特許番号
US07618972B2

反応ノート

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