HCID 68441993、化合物 → Methyl 2-oxo-2,3-dihydro-1h-pyrido[2,3-b][1,4]thiazine-7-carboxylate
反応式
[CH3:1][O:2][C:3](=[O:19])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([S:13][CH2:14][C:15](OC)=[O:16])=[N:6][CH:5]=1>C(O)(=O)C.[Fe]>[CH3:1][O:2][C:3]([C:4]1[CH:5]=[N:6][C:7]2[S:13][CH2:14][C:15](=[O:16])[NH:10][C:8]=2[CH:9]=1)=[O:19]参加物
4
反応条件
- 温度
- 60 °C
実験手順
6-Methoxycarbonylmethylsulfanyl-5-nitro-nicotinic acid methyl ester (1.0 g) in acetic acid (50 mL) was treated with iron powder (10 g) and the mixture was stirred and heated at 60° C. for 1 hour, cooled and filtered. The filtrate was evaporated, treated with sodium bicarbonate solution and extracted with warm chloroform. It was dried (anhydrous sodium sulfate) and evaporated to give a white solid (0.85 g).
後処理
- temperaturecooled
- filtrationfiltered
- customThe filtrate was evaporated
- additiontreated with sodium bicarbonate solution
- extractionextracted with warm chloroform
- dry with materialIt was dried (anhydrous sodium sulfate)
- customevaporated
出典と根拠
- ORDレコード
- ord-60edfad43bed43e7a7aa6163017b04fa
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07618959B2
反応ノート
読み込み中…