Diethyl Oxalate → 4-(3,4,5-Trifluorobenzyl)morpholine-2,3-dione

HRID 1436084

反応式

HRID 1436084 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:14])[C:12]=1[F:13])[CH2:5][NH:6]CCO.[C:15]([O:22][CH2:23][CH3:24])(=[O:21])[C:16]([O:18]CC)=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:14])[C:12]=1[F:13])[CH2:5][N:6]1[CH2:24][CH2:23][O:22][C:15](=[O:21])[C:16]1=[O:18]

参加物

3

反応物 2

HCID 7268Diethyl OxalateHCID 63050512HCID 63050512、化合物

生成物 1

HCID 690103374-(3,4,5-Trifluorobenzyl)morpholine-2,3-dione

反応条件

温度
170 °C

実験手順

A mixture of 2-[(3,4,5-trifluorobenzyl)amino]ethanol (6.91 g) and diethyl oxalate (20 mL) was stirred at 170° C. for one hour. The reaction solution was concentrated under reduced pressure, and then a diethyl ether was added to the residue. The precipitated crystals were collected by filtration and then air-dried to obtain 7.38 g of the title compound.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. additiona diethyl ether was added to the residue
  3. filtrationThe precipitated crystals were collected by filtration
  4. customair-dried

出典と根拠

ORDレコード
ord-94e074c546c94546a00db6bf96662b77
出典データセット
uspto-grants-2009_11
特許番号
US07618960B2

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