関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Oxalate | HCID 7268 | — |
| 反応物 | 2-{[(3,4,5-Trifluorophenyl)methyl]amino}ethan-1-ol | HCID 63050512 | — |
| 生成物 | 4-(3,4,5-Trifluorobenzyl)morpholine-2,3-dione | HCID 69010337 | — |
反応手順
A mixture of 2-[(3,4,5-trifluorobenzyl)amino]ethanol (6.91 g) and diethyl oxalate (20 mL) was stirred at 170° C. for one hour. The reaction solution was concentrated under reduced pressure, and then a diethyl ether was added to the residue. The precipitated crystals were collected by filtration and then air-dried to obtain 7.38 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07618960B2 |
|---|
| 出典データセット | uspto-grants-2009_11 |
|---|
| ORD ID | ord-94e074c546c94546a00db6bf96662b77 |
|---|
| 出典メモ | uspto-grants-2009_11 |
|---|
