1-(2-Chlorophenyl)-2-(4-chlorophenyl)ethanone → 2-Bromo-1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone

HRID 1436160ノート

反応式

HRID 1436160 の反応式
[Br-:1].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.[Cl:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[C:41](=[O:50])[CH2:42][C:43]1[CH:48]=[CH:47][C:46]([Cl:49])=[CH:45][CH:44]=1>C1COCC1.ClCCl>[Br:1][CH:42]([C:43]1[CH:44]=[CH:45][C:46]([Cl:49])=[CH:47][CH:48]=1)[C:41]([C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=1[Cl:34])=[O:50]

参加物

5

反応物 2

HCID 3483121-(2-Chlorophenyl)-2-(4-chlorophenyl)ethanoneHCID 17977687Phenyltrimethylammonium bromide dibromide

生成物 1

HCID 177481382-Bromo-1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

29.54 g of phenyltrimethylammonium tribromide are added to a solution of 20.83 g of 1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone in THF. The homogeneous solution is stirred at room temperature for 1 hour 15 minutes. The reaction medium is filtered and concentrated to dryness. The crude reaction product is taken up in dichloromethane and washed successively with water, with aqueous Na2CO3 solution and then with water. The organic phase is dried over Na2SO4, filtered and concentrated to dryness by distilling off the solvent under reduced pressure. The product is obtained in the form of an oil that crystallizes slowly. The crystals are washed with a minimum amount of ethanol to give the expected product.

後処理

  1. filtrationThe reaction medium is filtered
  2. concentrationconcentrated to dryness
  3. customThe crude reaction product
  4. washwashed successively with water, with aqueous Na2CO3 solution
  5. dry with materialThe organic phase is dried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated to dryness
  8. distillationby distilling off the solvent under reduced pressure
  9. customThe product is obtained in the form of an oil
  10. customthat crystallizes slowly
  11. washThe crystals are washed with a minimum amount of ethanol

出典と根拠

ORDレコード
ord-c5d7157c024e456fb8a3d99fec778240
出典データセット
uspto-grants-2009_11
特許番号
US07618991B2

反応ノート

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