Methyl iodide → N-(4-Methoxyphenyl)-N-methyl-2-phenylquinazolin-4-amine

反応式

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:11]=2)=[CH:5][CH:4]=1.[CH3:26]I>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:11]=2)[CH3:26])=[CH:7][CH:8]=1

参加物

反応物 2

HCID 6328Methyl iodide

HCID 719284N-(4-methoxyphenyl)-2-phenylquinazolin-4-amine

生成物 1

HCID 57938808N-(4-Methoxyphenyl)-N-methyl-2-phenylquinazolin-4-amine

実験手順

The title compound was prepared from (4-methoxy-phenyl)-(2-phenyl-quinazolin-4-yl)-amine (51 mg, 0.16 mmol) and methyl iodide (0.07 ml, 1.09 mmol) by a procedure similar to Example 36. 1H NMR (CDCl3): 8.64-8.61 (m, 2H), 7.90 (d, J=8.4 Hz, 1H), 7.59-7.48 (m, 4H), 7.18-7.14 (m, 2H), 7.08-6.98 (m, 2H), 6.94-6.91 (m, 2H), 3.85 (s, 3H), 3.73 (s, 3H).

出典と根拠

ORDレコード: ord-8e2de9e7e7594382a09814e21b56e0e7
出典データセット: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07618975B2

反応ノート

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