Hydrogen Bromide → 2-Bromo-4-(4-chloro-3-fluorophenyl)-1,3-thiazole
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][S:10][C:11]#[N:12])=[CH:4][C:3]=1[F:14].[BrH:15]>>[Br:15][C:11]1[S:10][CH:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([F:14])[CH:4]=2)[N:12]=1参加物
3
実験手順
In the same manner as described in step 5 of Example 78, using 1-(4-chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone (2.45 g, 10.7 mmol), prepared in the previous step, and hydrogen bromide (30% in acetic acid, 16 mL), the solid was collected by suction filtration to give 2-bromo-4-(4-chloro-3-fluorophenyl)-1,3-thiazole (2.1 g, 68%). The material was used without further purification, MS (ES) m/z 293[M+H+].
後処理
- filtrationthe solid was collected by suction filtration
出典と根拠
- ORDレコード
- ord-7b5dcaa899074c9fa5e490f8bc29c539
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07618990B2
反応ノート
読み込み中…