Water → 4-(2-Amino-1,3-thiazol-4-yl)benzonitrile
反応式
[NH2:1][C:2]([NH2:4])=[S:3].[C:5]([C:7]1[CH:16]=[CH:15][C:10]([C:11](=O)[CH2:12]Br)=[CH:9][CH:8]=1)#[N:6].[OH-].[Na+].O>C(O)C>[NH2:1][C:2]1[S:3][CH:12]=[C:11]([C:10]2[CH:15]=[CH:16][C:7]([C:5]#[N:6])=[CH:8][CH:9]=2)[N:4]=1参加物
6
実験手順
Thiourea (0.76 g, 10 mmol) was added to 4-cyanophenacyl bromide (2.0 g, 8.9 mmol) in ethanol (20 mL), and the reaction heated under reflux. After 45 min, the mixture was cooled to room temperature, and poured into 2N NaOH (10 mL)/water (40 mL). The precipitate was collected and air-dried to give 4-(2-amino-thiazol-4-yl)benzonitrile (1.6 g, 90%), which was used without further characterization.
後処理
- temperaturethe reaction heated
- temperatureunder reflux
- customThe precipitate was collected
- customair-dried
出典と根拠
- ORDレコード
- ord-f829c169ee5646be8d2dcd12e1074985
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07618990B2
反応ノート
読み込み中…