2-((2S)-2-Dibenzylamino-1-hydroxy-3-phenylpropyl)-6-ethylpiperidine-1-carboxylic acid tert-butyl ester → 2-((2S)-2-Amino-1-hydroxy-3-phenylpropyl)-6-ethylpiperidine-1-carboxylic acid tert-butyl ester

HRID 1436499ノート

反応式

HRID 1436499 の反応式
[C:1]([O:5][C:6]([N:8]1[CH:13]([CH2:14][CH3:15])[CH2:12][CH2:11][CH2:10][CH:9]1[CH:16]([OH:40])[C@@H:17]([N:25](CC1C=CC=CC=1)CC1C=CC=CC=1)[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[OH-].[Pd+2].[OH-]>[C:1]([O:5][C:6]([N:8]1[CH:13]([CH2:14][CH3:15])[CH2:12][CH2:11][CH2:10][CH:9]1[CH:16]([OH:40])[C@@H:17]([NH2:25])[CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

参加物

5

反応物 2

HCID 690159252-((2S)-2-Dibenzylamino-1-hydroxy-3-phenylpropyl)-6-ethylpiperidine-1-carboxylic acid tert-butyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 690144752-((2S)-2-Amino-1-hydroxy-3-phenylpropyl)-6-ethylpiperidine-1-carboxylic acid tert-butyl ester収率 95%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

Stir 2-((2S)-2-dibenzylamino-1-hydroxy-3-phenylpropyl)-6-ethylpiperidine-1-carboxylic acid tert-butyl ester-Isomer 2 (0.7 g, 1.23 mmol) and 20% palladium hydroxide (0.2 g, 50% wet) in methanol (10 mL) under a balloon of hydrogen gas at room temperature for 2 days. Filter the suspension through a pad of filtering agent, wash with methanol and concentrate to give the title compound (0.4 g, 95%).

後処理

  1. filtrationFilter the suspension through a pad
  2. filtrationof filtering agent
  3. washwash with methanol
  4. concentrationconcentrate

出典と根拠

ORDレコード
ord-26ca0cc48fea4d77a5a9d91978d745de
出典データセット
uspto-grants-2009_11
特許番号
US07618978B2

反応ノート

読み込み中…