2-(R)-[2-(R)-(Benzhydrylidene-amino)-1-(S)-hydroxy-3-phenylpropyl]-4-(5-methyl-hexanoyl)-piperazine-1-carboxylic acid tert-butyl ester → 2-(R)-(2-(R)-Amino-1-(S)-hydroxy-3-phenyl-propyl)-4-(5-methylhexanoyl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 1436514ノート

反応式

HRID 1436514 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:21])[CH2:15][CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:10][C@@H:9]1[C@@H:22]([OH:45])[C@H:23]([N:31]=C(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:21])[CH2:15][CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:10][C@@H:9]1[C@@H:22]([OH:45])[C@H:23]([NH2:31])[CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

参加物

4

反応物 1

HCID 866153782-(R)-[2-(R)-(Benzhydrylidene-amino)-1-(S)-hydroxy-3-phenylpropyl]-4-(5-methyl-hexanoyl)-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 690176622-(R)-(2-(R)-Amino-1-(S)-hydroxy-3-phenyl-propyl)-4-(5-methylhexanoyl)-piperazine-1-carboxylic acid tert-butyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Dissolve 2-(R)-[2-(R)-(Benzhydrylideneamino)-1-(S)-hydroxy-3-phenyl-propyl]-4-(5-methylhexanoyl)-piperazine-1-carboxylic acid tert-butyl ester (103 mg, 0.17 mmol) in 2 ml of methanol and add palladium (10% on C, 30 mg). Stir under 1 atmosphere of H2 for 24 h and filter through celite, eluting with methanol. Concentrate to dryness to provide the title compound.

後処理

  1. filtrationfilter through celite
  2. washeluting with methanol
  3. concentrationConcentrate to dryness

出典と根拠

ORDレコード
ord-4e9b9a9de5d14ad2a6c88b542f6a7030
出典データセット
uspto-grants-2009_11
特許番号
US07618978B2

反応ノート

読み込み中…