Hydrochloric Acid → (S)-2-sec-Butylamino-6-cyano-isonicotinic acid
反応式
C[O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10]#[N:11])[N:7]=[C:6]([NH:12][C@H:13]([CH2:15][CH3:16])[CH3:14])[CH:5]=1.[OH-].[Na+].Cl>CO>[C@@H:13]([NH:12][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([C:10]#[N:11])[N:7]=1)[C:3]([OH:17])=[O:2])([CH2:15][CH3:16])[CH3:14]参加物
5
実験手順
Dissolve (S)-2-sec-butylamino-6-cyano-isonicotinic acid methyl ester (250 mg, 0.93 mmol) in methanol (3 mL). Slowly add 2 N NaOH (1.5 mL) and stir overnight at room temperature. Acidify to about pH=6 with 5 N HCl and concentrate. Dilute with ethyl acetate (20 mL) and wash the organic layer with saturated aqueous sodium chloride, dry (magnesium sulfate) and concentrate to give the title compound.
後処理
- concentrationconcentrate
- additionDilute with ethyl acetate (20 mL)
- washwash the organic layer with saturated aqueous sodium chloride
- dry with materialdry (magnesium sulfate)
- concentrationconcentrate
出典と根拠
- ORDレコード
- ord-2d2e60ce8855454089bfcecd37233cef
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07618978B2
反応ノート
読み込み中…