Sodium methanethiolate → HCID 69018301、化合物
反応式
[CH3:1][S-:2].[Na+].Cl[CH2:5][C@@H:6]([NH:16][C:17](=[O:19])[CH3:18])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1>O1CCCC1>[CH3:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][C@H:6]([NH:16][C:17](=[O:19])[CH3:18])[CH2:5][S:2][CH3:1])=[CH:9][CH:10]=1参加物
4
実験手順
4 g of sodium thiomethoxide are added at 0-5° C. to a solution of 13.8 g of N-[(1S)-2-chloro-1-(4-methoxybenzyl)ethyl]acetamide in 60 ml of tetra-hydrofuran. After returning to ambient temperature, the suspension is filtered and the solid is washed with 2×10 ml of tetrahydrofuran. The filtrate is concentrated to dryness, providing 14 g of N-[(1S)-1-(4-methoxybenzyl)-2-(methylthio)ethyl]acetamide.
後処理
- customAfter returning to ambient temperature
- filtrationthe suspension is filtered
- washthe solid is washed with 2×10 ml of tetrahydrofuran
- concentrationThe filtrate is concentrated to dryness
出典と根拠
- ORDレコード
- ord-b11865f68a124086b87a7e00908f03b8
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07619116B2
反応ノート
読み込み中…