Hydrazine hydrate (1:1) → 2-Hydrazinyl-5-methoxypyridine

HRID 1437258ノート

反応式

HRID 1437258 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][N:3]=1.O.[NH2:11][NH2:12]>>[NH:11]([C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][N:3]=1)[NH2:12]

参加物

3

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 151690002-Chloro-5-methoxypyridine

生成物 1

HCID 230902452-Hydrazinyl-5-methoxypyridine

実験手順

The above-obtained 2-chloro-5-methoxypyridine (4.0 g) in hydrazine monohydrate (30 mL) was stirred at 100° C. for 24 hours, and then cooled in air. The reaction solvent was removed under reduced pressure, and the residue was partitioned by use of chloroform and aqueous 1N sodium hydroxide. The organic layer was dried over magnesium sulfate anhydrate, followed by filtration. The solvent was removed under reduced pressure, to thereby give 2-hydrazino-5-methoxypyridine as an oily product (705 mg, 18%).

後処理

  1. temperaturecooled in air
  2. customThe reaction solvent was removed under reduced pressure
  3. customthe residue was partitioned by use of chloroform and aqueous 1N sodium hydroxide
  4. dry with materialThe organic layer was dried over magnesium sulfate anhydrate
  5. filtrationfollowed by filtration
  6. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-5ef3b5688d254272ae3d74ff557b17fd
出典データセット
uspto-grants-2009_11
特許番号
US07622471B2

反応ノート

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