Tetrahydrofuran → 2-Oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-7-carbaldehyde

HRID 1437350ノート

反応式

HRID 1437350 の反応式
[OH:1][CH2:2][C:3]1[N:13]=[CH:12][C:6]2[O:7][CH2:8][C:9](=[O:11])[NH:10][C:5]=2[CH:4]=1.C1COCC1>[O-2].[O-2].[Mn+4].ClCCCl>[O:11]=[C:9]1[CH2:8][O:7][C:6]2[CH:12]=[N:13][C:3]([CH:2]=[O:1])=[CH:4][C:5]=2[NH:10]1

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 21873679HCID 21873679、化合物

生成物 1

HCID 218736022-Oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-7-carbaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 111,2-Dichloroethane溶媒

反応条件

温度
60 °C

実験手順

A mixture of the hydroxymethyloxazinone (h) (584 mg), manganese dioxide (2.3 g), THF (50 ml) and 1,2-dichloroethane (50 ml) was heated at 60° C. under argon for 20 hours. Filtration through kieselguhr and evaporation of solvent gave a solid which was triturated under EtOAc/hexane 1:3, filtered off and dried (383 mg).

後処理

  1. filtrationFiltration
  2. customthrough kieselguhr and evaporation of solvent
  3. customgave a solid which
  4. customwas triturated under EtOAc/hexane 1:3
  5. filtrationfiltered off
  6. customdried (383 mg)

出典と根拠

ORDレコード
ord-da07e9a5c0f947f68be1017a0335149a
出典データセット
uspto-grants-2009_11
特許番号
US07622481B2

反応ノート

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