HCID 86607259、化合物 → HCID 68699181、化合物
反応式
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:10][CH2:9][C@@H:8]([N:11]=[N+]=[N-])[C@H:7]([OH:14])[CH2:6]1)=[O:4]>CO.C(O)(=O)C.[Pd]>[C:3]([OH:4])(=[O:2])[CH3:5].[CH3:1][O:2][C:3]([C@@H:5]1[CH2:10][CH2:9][C@@H:8]([NH2:11])[C@H:7]([OH:14])[CH2:6]1)=[O:4]参加物
4
実験手順
A solution of azide (b) (18.4 g, 92 mmol) in methanol/acetic acid (360 ml/40 ml) was hydrogenated over 10% palladium on charcoal paste (50% w/w with water, 15 g) for 18 hours. The mixture was filtered through keiselguhr, evaporated, and then triturated with ether to afford a white solid that was isolated by filtration and dried in vacuo (15.6 g, 72%).
後処理
- filtrationThe mixture was filtered through keiselguhr
- customevaporated
- customtriturated with ether
- customto afford a white solid
- customthat was isolated by filtration
- customdried in vacuo (15.6 g, 72%)
出典と根拠
- ORDレコード
- ord-c90746d319ef432ea4412b68fed6f4e6
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07622481B2
反応ノート
読み込み中…