Methyl Isocyanate → HCID 86606822、化合物
反応式
[CH2:1]([C@H:8]1[C@@H:13]([O:14][CH2:15][C:16]2[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[C:18]([C:26]([F:29])([F:28])[F:27])[CH:17]=2)[CH2:12][CH2:11][NH:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:30][N:31]=[C:32]=[O:33]>C1COCC1>[CH2:1]([C@H:8]1[C@@H:13]([O:14][CH2:15][C:16]2[CH:17]=[C:18]([C:26]([F:29])([F:27])[F:28])[CH:19]=[C:20]([C:22]([F:23])([F:24])[F:25])[CH:21]=2)[CH2:12][CH2:11][N:10]([C:32]([NH:31][CH3:30])=[O:33])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
To a solution of the compound (0.39 g) obtained in Example 404 in THF (10 ml), methyl isocyanate (0.12 ml) was added, and the reaction mixture was stirred at room temperature for 17 hours. The solvent was evaporated under reduced pressure, and then the obtained residue was isolated and purified by silica gel column chromatography (ethyl acetate) to obtain the title compound as colorless crystals (0.27 g, 61%).