Methanesulfonyl chloride → N-(6-Chloro-2-methylpyridin-3-yl)methanesulfonamide
反応式
[NH2:1][C:2]1[C:3]([CH3:9])=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[CH3:10][S:11](Cl)(=[O:13])=[O:12]>N1C=CC=CC=1>[Cl:8][C:5]1[N:4]=[C:3]([CH3:9])[C:2]([NH:1][S:11]([CH3:10])(=[O:13])=[O:12])=[CH:7][CH:6]=1参加物
4
実験手順
A mixture of 3-amino-6-chloro-2-picoline (2.0 g, 14.0 mmol) and methanesulfonyl chloride (1.92 g, 16.8 mmol) in pyridine (40 ml) was stirred for 1 hour at room temperature. After removal of the solvent, the resulting crude product was purified by silica gel column chromatography, eluting with hexane/EtOAc (3:2), to afford 1.70 g (55% yield) of the title compound as pale yellow solids.
後処理
- customAfter removal of the solvent
- customthe resulting crude product was purified by silica gel column chromatography
- washeluting with hexane/EtOAc (3:2)
出典と根拠
- ORDレコード
- ord-eadb516d81764d858f156cf53fa201c5
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07622589B2
反応ノート
読み込み中…