Pyrrolidine → 2-(Pyrrolidin-1-yl)-6-(trifluoromethyl)pyridine-3-carboxylic acid
反応式
Cl[C:2]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH2:19][CH2:18][CH2:17][CH2:16]1参加物
3
実験手順
A mixture of 2-chloro-6-(trifluoromethyl)nicotinic acid (purchased from APOLLO, 5.0 g, 22.2 mmol) and pyrrolidine (40 ml, 562 mmol) was stirred for 24 hours at room temperature according to J. Med. Chem., 2005, 48, 71-90). Then the reaction mixture was evaporated in vacuo to give the title compound (5.5 g, 95%).
後処理
- customThen the reaction mixture was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-08f513b71c6349f99ec8f19e24965fb3
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07622589B2
反応ノート
読み込み中…