2-(Methylamino)-3-nitrobenzoic acid → HCID 18355255、化合物
反応式
[CH3:1][NH:2][C:3]1[C:11]([N+:12]([O-])=O)=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[H][H]>CCOC(C)=O.CCO.[Pd]>[NH2:12][C:11]1[C:3]([NH:2][CH3:1])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6]参加物
6
実験手順
A mixture of 2-methylamino-3-nitro-benzoic acid and 10% Pd/C (300 mg) in EtOAc (5 mL) and EtOH (5 mL) was stirred in an atmosphere of hydrogen over night. The mixture was filtered though a pad of Celite and the filter cake was washed with EtOAc. The filtrate was concentrated under reduced pressure to provide 3-amino-2-methylamino-benzoic acid.
後処理
- filtrationThe mixture was filtered though a pad of Celite
- washthe filter cake was washed with EtOAc
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-8c2618528d2244d888c82782936c75f8
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07622583B2
反応ノート
読み込み中…