Hydrochloric Acid → N-(4-methoxybenzoyl)-phenylalanyltyrosine

HRID 1439008ノート

反応式

HRID 1439008 の反応式
[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:22]([OH:24])=[O:23])[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:25][O:26][C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1.Cl>[OH-].[Na+]>[CH3:25][O:26][C:27]1[CH:35]=[CH:34][C:30]([C:31]([NH:1][C@H:2]([C:10]([NH:12][C@H:13]([C:22]([OH:24])=[O:23])[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[O:11])[CH2:3][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[O:32])=[CH:29][CH:28]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 7477p-Anisoyl chlorideHCID 515709Phe-Tyr

生成物 1

HCID 54084741N-(4-methoxybenzoyl)-phenylalanyltyrosine収率 56.4%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒2 回

実験手順

In 20 ml of 1N sodium hydroxide solution, 3.28 g of phenylalanyltyrosine was dissolved and the solution was cooled with ice. To the cold solution were added dropwise 1.7 g of 4-methoxybenzoylchloride and 10 ml of 1N sodium hydroxide solution. After stirring for 2 hours, the mixture was neutralized with hydrochloric acid and extracted with ethyl acetate. The extract was washed with water, dried and concentrated to dryness. The residue was crystallized from ethyl acetate to give 2.6 g of N-(4-methoxybenzoyl)-phenylalanyltyrosine in a yield of 56%.

後処理

  1. temperaturethe solution was cooled with ice
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water
  4. customdried
  5. concentrationconcentrated to dryness
  6. customThe residue was crystallized from ethyl acetate

出典と根拠

ORDレコード
ord-730a6d8d9b904f4996e0ab14cea922e5
出典データセット
uspto-grants-1977_11
特許番号
US04057629

反応ノート

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