Chloroacetonitrile → HCID 20393696、化合物

HRID 1439213ノート

反応式

HRID 1439213 の反応式
[C:1]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([Cl:16])[C:10]=1[Cl:17])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:19][C:20]#[N:21].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[C:1]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:19][C:20]#[N:21])=[C:11]([Cl:16])[C:10]=1[Cl:17])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 14009997(2,3-Dichloro-4-hydroxyphenyl)(phenyl)methanone

生成物 1

HCID 20393696HCID 20393696、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 26.70 g. (0.10 mole) of 4-benzoyl-2,3-dichlorophenol, 7.40 g. (0.10 mole) of chloroaceto nitrile, 10.40 g. (0.15 mole) of anhydrous K2CO3 and catalytic amount of KI in 200 ml. of acetone was refluxed overnight. The residue was triturated with ether and the product was collected by filtration and dried to yield 22.80 g. (75%); m.p. 110°-112°. This product was used in the next step without further purification.

後処理

  1. additionA mixture of 26.70 g
  2. customThe residue was triturated with ether
  3. filtrationthe product was collected by filtration
  4. customdried
  5. customto yield 22.80 g
  6. customThis product was used in the next step without further purification

出典と根拠

ORDレコード
ord-a6cb90a5f50c4dedba1a89701683a8a0
出典データセット
uspto-grants-1977_11
特許番号
US04058559

反応ノート

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