Sodium Hydroxide → 8-Acetyl-8-phenyl-12-benzyloxyheptadecanoic acid

HRID 1439477ノート

反応式

HRID 1439477 の反応式
[C:1]([C:4]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)([CH2:16][CH2:17][CH2:18][CH:19]([O:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC)=[O:12])(=[O:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([C:4]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)([CH2:16][CH2:17][CH2:18][CH:19]([O:25][CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 21397385HCID 21397385、化合物

生成物 1

HCID 213974108-Acetyl-8-phenyl-12-benzyloxyheptadecanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of ethyl 8-acetyl-8-phenyl-12-benzyloxyheptadecanoate (14 g., crude), sodium hydroxide (2.0 g., 0.05 mole) and methanol (150 ml.) is stirred for 48 hours. The methanol is removed in vacuo; and the residual oil is poured into H2 0 (100 ml.), acidified with 6 N HCl (100 ml.), extracted with ether, and the combined ether extracts dried over anhydrous Na2SO4. The ether is removed in vacuo, and the residual oil is chromatographed through a silica gel column (95% CHCH3 -5% MeOH) to obtain 8-acetyl-8-phenyl-12-benzyloxyheptadecanoic acid (1.43 g., slightly impure).

後処理

  1. customThe methanol is removed in vacuo
  2. additionand the residual oil is poured into H2 0 (100 ml.)
  3. extractionextracted with ether
  4. dry with materialthe combined ether extracts dried over anhydrous Na2SO4
  5. customThe ether is removed in vacuo
  6. customthe residual oil is chromatographed through a silica gel column (95% CHCH3 -5% MeOH)

出典と根拠

ORDレコード
ord-ac5a6e5635654f21bb97145746e4a57c
出典データセット
uspto-grants-1977_11
特許番号
US04059601

反応ノート

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