Ethylene Oxide → 2-[Benzyl(2-hydroxyethyl)amino]benzamide

HRID 1439612ノート

反応式

HRID 1439612 の反応式
[CH2:1]([NH:8][C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([NH2:13])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]1[O:20][CH2:19]1>C(O)(=O)C>[CH2:1]([N:8]([CH2:18][CH2:19][OH:20])[C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([NH2:13])=[O:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 6354Ethylene OxideHCID 11345158HCID 11345158、化合物

生成物 1

HCID 203383632-[Benzyl(2-hydroxyethyl)amino]benzamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

o-Benzylaminobenzamide (62 g) was added to a cold solution of 85 ml ethylene oxide in 500 ml acetic acid, the mixture stirred 22 hours at room temperature and concentrated on the rotovap to remove 250 ml acetic acid. The remainder was made alkaline with 10% NaOH and the solid filtered washed with water and recrystallized from 300 ml ethyl acetate to give 48.5 g. product, m.133-7°.

後処理

  1. concentrationconcentrated on the rotovap
  2. customto remove 250 ml acetic acid
  3. filtrationthe solid filtered
  4. washwashed with water
  5. customrecrystallized from 300 ml ethyl acetate
  6. customto give 48.5 g
  7. custom133-7°

出典と根拠

ORDレコード
ord-6b167cf4c02242e99b2eb72f8e049521
出典データセット
uspto-grants-1977_11
特許番号
US04060526

反応ノート

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