3-[4-(Propan-2-yl)cyclohexyl]propanoic acid → 1,5-Bis[4-(propan-2-yl)cyclohexyl]pentan-3-one

HRID 1439774ノート

反応式

HRID 1439774 の反応式
[CH:1]([CH:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([OH:14])=O)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]>[Fe]>[CH:1]([CH:4]1[CH2:5][CH2:6][CH:7]([CH2:10][CH2:11][C:12](=[O:14])[CH2:11][CH2:10][CH:7]2[CH2:6][CH2:5][CH:4]([CH:1]([CH3:2])[CH3:3])[CH2:9][CH2:8]2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

参加物

3

反応物 1

HCID 213966513-[4-(Propan-2-yl)cyclohexyl]propanoic acid

生成物 1

HCID 213966471,5-Bis[4-(propan-2-yl)cyclohexyl]pentan-3-one

試薬・触媒・溶媒 1

HCID 23925Iron触媒

反応条件

温度
290 °C

実験手順

3-(4-Isopropylcyclohexyl)propionic acid (39.7 g., 0.20 mole) and iron (hydrogen reduced, 6.15 g., 0.11 mole) is heated for 1.5 hours at 195° C. under a nitrogen atmosphere. After that time, the temperature is increased to 290° C. and maintained at that temperature for 3 hours. The cooled reaction mass is extracted well with ether, filtered through Celite, and the ethereal extracts concentrated under vacuum. The residue is stripped under vacuum to leave the product, 17.3 g. (51%).

後処理

  1. temperaturemaintained at that temperature for 3 hours
  2. customThe cooled reaction mass
  3. extractionis extracted well with ether
  4. filtrationfiltered through Celite
  5. concentrationthe ethereal extracts concentrated under vacuum
  6. customto leave the product, 17.3 g

出典と根拠

ORDレコード
ord-b853a1bd71234ec8bd957d12440ef76a
出典データセット
uspto-grants-1977_11
特許番号
US04060639

反応ノート

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